a simplified approach to disulfide connectivity prediction from protein sequences一个简化的二硫化方法连接从蛋白质序列预测.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A simplified approach to disulfide connectivity prediction from protein sequences Marc Vincent, Andrea Passerini, Matthieu Labbé and Paolo Frasconi* Address: Machine Learning and Neural Networks Group, Dipartimento di Sistemi e Informatica, Università degli Studi di Firenze, Via di Santa Marta 3, 50139 Firenze, Italy Email: Marc Vincent - vincent@dsi.unifi.it; Andrea Passerini - passerini@dsi.unifi.it; Matthieu Labbé - labbe@dsi.unifi.it; Paolo Frasconi* - p- f@dsi.unifi.it * Corresponding author Published: 14 January 2008 Received: 4 September 2007 Accepted: 14 January 2008 BMC Bioinformatics 2008, 9:20 doi:10.1186/1471-2105-9-20 This article is available from: /1471-2105/9/20 © 2008 Vincent et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Prediction of disulfide bridges from protein sequences is useful for characterizing structural and functional properties of proteins. Several methods based on different machine learning algorithms have been applied to solve this problem and public domain prediction services exist. These methods are however still potentially subject to significant improvements both in terms of prediction accuracy and overall architectural co