原创力文档adjuvant chemotherapy of pt1a and pt1b breast carcinoma results from the nemesi study辅助化疗pt1a和pt1b乳腺癌nemesi研究的结果.pdfVIP
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adjuvant chemotherapy of pt1a and pt1b breast carcinoma results from the nemesi study辅助化疗pt1a和pt1b乳腺癌nemesi研究的结果
Gori et al. BMC Cancer 2012, 12:158
/1471-2407/12/158
RESEARCH ARTICLE Open Access
Adjuvant chemotherapy of pT1a and pT1b breast
carcinoma: results from the NEMESI study
1,13* 2 3 1 3 4
Stefania Gori , Matteo Clavarezza , Salvatore Siena , Jennifer Foglietta , Emiliana Tarenzi , Monica Giordano ,
Annamaria Molino5 6 7 8 9 10
, Claudio Graiff , Vittorio Fusco , Oscar Alabiso , Editta Baldini , Teresa Gamucci ,
Giuseppe Altavilla11, Davide Dondi12 and Marco Venturini2
Abstract
Background: The prognosis of pT1a-pT1b breast cancer (BC) used to be considered very good, with a 10-y RFS of
90%. However, some retrospective studies reported a 10-y RFS of 81%–86% and suggested benefit from adjuvant
systemic therapy.
Methods: To evaluate the variables that determined the choice of adjuvant chemotherapy and the type of
chemotherapy delivered in pT1a-pT1b BC, we analysed the small tumours enrolled in the NEMESI study.
Results: Out of 1,894 patients with pathological stage I-II BC enrolled in NEMESI, 402 (21.2%) were pT1a-pT1b.
Adjuvant chemotherapy was delivered in 127/402 (31.59%). Younger age, grading G3, high proliferative index,
ER-negative and HER2-positive status were significantly associated with the decision to administer adjuvant
chemotherapy. An anthracycline without taxane regimen was administered in 59.1% of patients, anthracycline with
taxane in 24.4%, a CMF-like regimen in 14.2% and taxane in 2.4%. Adjuvant chemotherapy was administered in
88.4% triple-negative and 73.46% HER2-positive pT1a-pT1b BC. Adjuvant trastuzumab was delivered in 30/49
HER2-pos
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