adverse effect profile of trichlormethiazide a retrospective observational study不利影响的trichlormethiazide回顾性观察研究.pdfVIP

Takahashi et al. Cardiovascular Diabetology 2011, 10:45 CARDIO /content/10/1/45 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Adverse effect profile of trichlormethiazide: a retrospective observational study Yasuo Takahashi1,2†, Yayoi Nishida1,2†, Tomohiro Nakayama3 and Satoshi Asai1,2* Abstract Background: Trichlormethiazide, a thiazide diuretic, was introduced in 1960 and remains one of the most frequently used diuretics for treating hypertension in Japan. While numerous clinical trials have indicated important side effects of thiazides, e.g., adverse effects on electrolytes and uric acid, very few data exist on serum electrolyte levels in patients with trichlormethiazide treatment. We performed a retrospective cohort study to assess the adverse effects of trichlormethiazide, focusing on serum electrolyte and uric acid levels. Methods: We used data from the Clinical Data Warehouse of Nihon University School of Medicine obtained between Nov 1, 2004 and July 31, 2010, to identify cohorts of new trichlormethiazide users (n = 99 for 1 mg, n = 61 for 2 mg daily dosage) and an equal number of non-users (control). We used propensity-score matching to adjust for differences between users and control for each dosage, and compared serum chemical data including serum sodium, potassium, uric acid, creatinine and urea nitrogen. The mean exposure of trichlormethiazide of 1 mg and 2 mg users was 58 days and 64 days, respectively. Results: The mean age was 66 years, and 55% of trichlormethiazide users of the 1 mg dose were female. In trichlormethiaz