原创力文档activated il-23il-17 pathway closely correlates with increased foxp3 expression in livers of chronic hepatitis b patients激活il-23il-17通路与增加密切相关foxp3表达在慢性乙型肝炎患者肝脏.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
activated il-23il-17 pathway closely correlates with increased foxp3 expression in livers of chronic hepatitis b patients激活il-23il-17通路与增加密切相关foxp3表达在慢性乙型肝炎患者肝脏
Activated IL-23/IL-17 pathway closely correlates
with increased Foxp3 expression in livers of
chronic hepatitis B patients
Wang et al.
Wang et al. BMC Immunology 2011, 12:25
/1471-2172/12/25 (14 April 2011)
Wang et al. BMC Immunology 2011, 12:25
/1471-2172/12/25
RESEARCH ARTICLE Open Access
Activated IL-23/IL-17 pathway closely correlates
with increased Foxp3 expression in livers of
chronic hepatitis B patients
1,2† 2† 2 2 3 3 2*
Qinghong Wang , Yanhua Zheng , Zemin Huang , Yi Tian , Jijun Zhou , Qing Mao , Yuzhang Wu and
Bing Ni2*
Abstract
Background: Foxp3 protein plays a critical role in mediating the inflammatory response and can inhibit the
proinflammatory IL-23/IL-17 pathway. However, the molecular interplay of Foxp3 and the IL-23/IL-17 pathway in
patients with chronic hepatitis B (CHB) remains unclear. To this end, we analyzed the expression patterns of Foxp3-
and IL-23/IL-17 pathway-related proinflammatory cytokines in 39 patients with acute-on-chronic liver failure, 71
patients with CHB and 32 healthy controls.
Results: Foxp3 expression was found to be elevated in and mainly expressed by the CD4+ T cell sub-population of
peripheral blood mononuclear cells and liver tissues of patients with hepatitis B. The intrahepatic expression of
Foxp3 strongly correlated with the copies of HBV DNA and the concentration of surface antigen, HBsAg. IL-23/IL-17
pathway-related proinflammatory cytokines were also found to be significantly increased in patients’ liver tissues, as
compared to healthy controls. Moreover, Foxp3 expression was strikingly correlated wit
您可能关注的文档
- a transcriptional-switch model for slr1738-controlled gene expression in the cyanobacterium synechocystisslr1738-controlled transcriptional-switch模型中的基因表达藻青菌集胞藻属.pdf
- a two-way interface between limited systems biology markup language and r之间的双向接口有限的系统生物学标记语言和r.pdf
- a unified approach to false discovery rate estimation一个统一的错误发现率估计方法.pdf
- a two-step site and mrna-level model for predicting microrna targets一个两步网站和mrna-level模型预测microrna的目标.pdf
- a unified computational model for revealing and predicting subtle subtypes of cancers一个统一的计算模型,揭示和预测微妙的子类型的癌症.pdf
- a two-stage approach for improved prediction of residue contact maps两阶段方法改进预测残留接触地图.pdf
- a temporal precedence based clustering method for gene expression microarray data基于时间优先的微阵列基因表达数据的聚类方法.pdf
- a unified approach to molecular epidemiology investigations tools and patterns in california as a case study for endemic shigellosis一个统一的分子流行病学方法调查工具和模式在加州为例对志贺氏菌病流行.pdf
- a unified framework for multi-locus association analysis of both common and rare variants一个统一的框架多位点关联分析常见和罕见变异.pdf
- a unique genetic code change in the mitochondrial genome of the parasitic nematode radopholus similis一个独特的遗传密码改变寄生线虫的线粒体基因组radopholus冲沙.pdf
- activation of macrophages by silicones phenotype and production of oxidant metabolites激活的巨噬细胞由硅树脂表型和氧化剂代谢物的生产.pdf
- activation of an amp-activated protein kinase is involved in post-diapause development of artemia franciscana encysted embryos活化蛋白激酶的激活参与post-diapause发展卤虫franciscana包绕的胚胎.pdf
- activating transcription factor-3 (atf3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (hsp90) inhibition转录激活因素3(atf3)函数作为一个肿瘤抑制结肠癌和上调后热休克蛋白90(一半)抑制.pdf
- actin binding domains direct actin-binding proteins to different cytoskeletal locations不同细胞骨架肌动蛋白结合域直接actin-binding蛋白质的位置.pdf
- activation of nuclear factor kappa b (nf-κb) by connective tissue growth factor (ccn2) is involved in sustaining the survival of primary rat hepatic stellate cells核转录因子的激活卡巴b(nf-κb)结缔组织生长因子(ccn2)是参与维持主要的大鼠肝星状细胞的生存.pdf
- activation of endogenous p53 by combined p19arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines b16 and c6激活内源性p53的单独基因转移和nutlin-3联合药物治疗模式在小鼠b16转椅和c6细胞行.pdf
- activation of mek1 or mek2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors激活mek1或mek2同种型足以完全改变肠道上皮细胞,引起转移性肿瘤的形成.pdf
- activation of tgf-beta signalling in breast cancer metastatic cells在转移性乳腺癌细胞激活及信号.pdf
- activation of the control reporter plasmids prl-tk and prl-sv40 by multiple gata transcription factors can lead to aberrant normalization of transfection efficiency激活控制记者的质粒prl-tk和prl-sv40由多个gata转录因子可导致异常的正常化转染效率.pdf
- activation of nag-1 via jnk signaling revealed an isochaihulactone-triggered cell death in human lncap prostate cancer cells通过物激活nag-1信号显示一个人类前列腺癌细胞lncap isochaihulactone-triggered细胞死亡.pdf
最近下载
- 《懂得爱：在亲密关系中成长》读书笔记.docx VIP
- 上海市中考语文专题复习：文言文虚词简表.pdf VIP
- 广西盐业公司的招聘试卷.pdf VIP
- 2025《民营经济促进法》解读课件PPT.pptx
- Haier海尔空调KFRd-120LW 7YAF81 KFRd-120LW 5YAF82 KFR-12ity 5YAF82用户手册.pdf
- 雪铁龙维修 手册 图DS_5LS_Owner_Book_ZH.pdf VIP
- 烟风煤支吊架设计手册-新版.pdf VIP
- 长期卧床鼻饲患者的护理ppt.pptx VIP
- 教学能力大赛教案--智慧工厂的安全策略之VLAN的划分.docx VIP
- GB 6246-2011 消防水带标准规范‘’.pdf
文档评论（0）