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activation of tgf-beta signalling in breast cancer metastatic cells在转移性乳腺癌细胞激活及信号
Available online /supplements/12/S2
Breast Cancer Research Volume 10 Suppl 2, 2008
Meeting Abstracts
Breast Cancer Research 2008
The Royal Society, London, UK
13 May 2008
Published online: 13 May 2008
These abstracts are available online at /supplements/10/S2
© 2008 BioMed Central Ltd
KEYNOTE LECTURES These variants remain unclassified because in the majority of cases
it is not possible to follow variants by cosegregation analysis, and
Abstracts not available at time of publication. the number of appropriate controls required to be certain that a
variant is absent in unaffected individuals is prohibitive. Currently,
L1 in silico algorithms try to distinguish between missense substi-
Chromosomal instability in the pathogenesis and tutions that are likely to be pathogenic and those that are not.
treatment of breast cancer These algorithms compile a multicomponent likelihood ratio that
integrates assessment methods ranging from conservation analy-
A Venkitaraman sis, co-occurrence of a deleterious allele in trans, and immuno-
Breast Cancer Res 2008, 10(Suppl 2):L1 (doi: 10.1186/bcr 1877) histochemical analysis [1-3]. What is missing from these ana
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