原创力文档a unified framework for managing provenance information in translational research一个统一的框架来管理出处信息转化研究.pdfVIP
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a unified framework for managing provenance information in translational research一个统一的框架来管理出处信息转化研究
Sahoo et al. BMC Bioinformatics 2011, 12:461
/1471-2105/12/461
RESEARCH ARTICLE Open Access
A unified framework for managing provenance
information in translational research
1,4* 1 3 1 2 1
Satya S Sahoo , Vinh Nguyen , Olivier Bodenreider , Priti Parikh , Todd Minning and Amit P Sheth
Abstract
Background: A critical aspect of the NIH Translational Research roadmap, which seeks to accelerate the delivery of
“bench-side” discoveries to patient’s “bedside,” is the management of the provenance metadata that keeps track of
the origin and history of data resources as they traverse the path from the bench to the bedside and back. A
comprehensive provenance framework is essential for researchers to verify the quality of data, reproduce scientific
results published in peer-reviewed literature, validate scientific process, and associate trust value with data and
results. Traditional approaches to provenance management have focused on only partial sections of the
translational research life cycle and they do not incorporate “domain semantics”, which is essential to support
domain-specific querying and analysis by scientists.
Results: We identify a common set of challenges in managing provenance information across the pre-publication
and post-publication phases of data in the translational research lifecycle. We define the semantic provenance
framework (SPF), underpinned by the Provenir upper-level provenance ontology, to address these challenges in the
four stages of provenance metadata:
(a) Provenance collection - during data generation
(b) Provenance representation - to support interoperability, reasoning, and incorporate domain semantics
(c) Provenance storage and propagation - t
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