activation of the steroid and xenobiotic receptor, sxr, induces apoptosis in breast cancer cells类固醇和异型生物质受体的激活,sxr,乳腺癌细胞发生凋亡.pdfVIP

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activation of the steroid and xenobiotic receptor, sxr, induces apoptosis in breast cancer cells类固醇和异型生物质受体的激活,sxr,乳腺癌细胞发生凋亡.pdf

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activation of the steroid and xenobiotic receptor, sxr, induces apoptosis in breast cancer cells类固醇和异型生物质受体的激活,sxr,乳腺癌细胞发生凋亡

BMC Cancer BioMed Central Research article Open Access Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells † † Suman Verma , Michelle M Tabb and Bruce Blumberg* Address: Department of Developmental and Cell Biology, 5205 McGaugh Hall, University of California, Irvine, CA 92697-2300, USA Email: Suman Verma - sverma@; Michelle M Tabb - michelle.tabb@; Bruce Blumberg* - blumberg@ * Corresponding author †Equal contributors Published: 5 January 2009 Received: 6 August 2008 Accepted: 5 January 2009 BMC Cancer 2009, 9:3 doi:10.1186/1471-2407-9-3 This article is available from: /1471-2407/9/3 © 2009 Verma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The steroid and xenobiotic receptor, SXR, is an orphan nuclear receptor that regulates metabolism of diverse dietary, endobiotic, and xenobiotic compounds. SXR is expressed at high levels in the liver and intestine, and at lower levels in breast and other tissues where its function was unknown. Since many breast cancer preventive and therapeutic compounds are SXR activators, we hypothesized that some beneficial effects of these compounds are mediated through SXR.