activation of nuclear factor kappa b (nf-κb) by connective tissue growth factor (ccn2) is involved in sustaining the survival of primary rat hepatic stellate cells核转录因子的激活卡巴b(nf-κb)结缔组织生长因子(ccn2)是参与维持主要的大鼠肝星状细胞的生存.pdfVIP

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activation of nuclear factor kappa b (nf-κb) by connective tissue growth factor (ccn2) is involved in sustaining the survival of primary rat hepatic stellate cells核转录因子的激活卡巴b(nf-κb)结缔组织生长因子(ccn2)是参与维持主要的大鼠肝星状细胞的生存.pdf

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Cell Communication and Signaling BioMed Central Research Open Access Activation of nuclear factor kappa B (NF-κB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells Runping Gao1,2 and David R Brigstock* 1,2,3 Address: 1Center for Cell and Vascular Biology, Childrens Research Institute, Columbus Ohio 43205 USA, 2Department of Surgery, The Ohio State University, Columbus, Ohio 43212 USA and 3Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43212 USA Email: Runping Gao - gao_runping@; David R Brigstock* - brigstod@ * Corresponding author Published: 22 November 2005 Received: 29 August 2005 Accepted: 22 November 2005 Cell Communication and Signaling 2005, 3:14 doi:10.1186/1478-811X-3-14 This article is available from: /content/3/1/14 © 2005 Gao and Brigstock; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. connective tissue growth factorCCN2hepatic stellate cellNF-κBsurvivalapoptosisfibrosis Abstract Background/Aims: Connective tissue growth factor (CCN2) is a matricellular protein that plays a role in hepatic stellate cell (HSC)-mediated fibrogenesis. The aim of this study was to investigate the regulation by CCN2 of cell survival pathways in primary HSC. Methods: Primary HSC were obtained by in situ enzymatic perfusion of rat liver. NF-κB activation was assessed by immunoblott