原创力文档algorithms for computing parsimonious evolutionary scenarios for genome evolution, the last universal common ancestor and dominance of horizontal gene transfer in the evolution of prokaryotes基因组进化算法计算吝啬的进化情况,最后一个共同祖先,水平基因转移占主导地位,在原核生物的进化.pdfVIP
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algorithms for computing parsimonious evolutionary scenarios for genome evolution, the last universal common ancestor and dominance of horizontal gene transfer in the evolution of prokaryotes基因组进化算法计算吝啬的进化情况,最后一个共同祖先,水平基因转移占主导地位,在原核生物的进化
BMC Evolutionary Biology BioMed Central
Research article Open Access
Algorithms for computing parsimonious evolutionary scenarios for
genome evolution, the last universal common ancestor and
dominance of horizontal gene transfer in the evolution of
prokaryotes
1 1 2
Boris G Mirkin , Trevor I Fenner , Michael Y Galperin and
Eugene V Koonin*2
Address: 1School of Information Systems and Computer Science, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
and 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Email: Boris G Mirkin - mirkin@dcs.bbk.ac.uk; Trevor I Fenner - trevor@dcs.bbk.ac.uk; Michael Y Galperin - galperin@;
Eugene V Koonin* - koonin@
* Corresponding author
Published: 6 January 2003 Received: 15 October 2002
Accepted: 6 January 2003
BMC Evolutionary Biology 2003, 3:2
This article is available from: /1471-2148/3/2
© 2003 Mirkin et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: Comparative analysis of sequenced genomes reveals numerous instances of
apparent horizontal gene transfer (HGT), at least in prokaryotes, and indicates that lineage-specific
gene loss might have been even more common in evolution. This complicates t
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