allele frequency misspecification effect on power and type i error of model-dependent linkage analysis of quantitative traits under random ascertainment等位基因频率misspecification影响权力和错误的依赖于模式的连锁分析的量化特征下随机确定.pdfVIP
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allele frequency misspecification effect on power and type i error of model-dependent linkage analysis of quantitative traits under random ascertainment等位基因频率misspecification影响权力和错误的依赖于模式的连锁分析的量化特征下随机确定
BMC Genetics BioMed Central
Research article Open Access
Allele frequency misspecification: effect on power and Type I error
of model-dependent linkage analysis of quantitative traits under
random ascertainment
1 2 3
Diptasri M Mandal* , Alexa JM Sorant , Larry D Atwood ,
2 2
Alexander F Wilson and Joan E Bailey-Wilson
Address: 1Department of Genetics Louisiana State University Health Sciences Center 533 Bolivar Street, CSRB 6-16 New Orleans, LA 70112 USA,
2National Human Genome Research Institute, NIH, Baltimore, MD, USA and 3Department of Neurology, Boston University School of Medicine,
Boston, MA, USA
Email: Diptasri M Mandal* - dmanda@; Alexa JM Sorant - ajms@; Larry D Atwood - lda@;
Alexander F Wilson - afw@; Joan E Bailey-Wilson - jebw@
* Corresponding author
Published: 20 April 2006 Received: 14 December 2005
Accepted: 20 April 2006
BMC Genetics 2006, 7:21 doi:10.1186/1471-2156-7-21
This article is available from: /1471-2156/7/21
© 2006 Mandal et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Studies of model-based linkage analysis show that trait or marker model
misspeci
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