allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression等位基因丢失乐队18号染色体上p11.3发生早,显示乳腺癌发展的异质性.pdfVIP

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allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression等位基因丢失乐队18号染色体上p11.3发生早,显示乳腺癌发展的异质性.pdf

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allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression等位基因丢失乐队18号染色体上p11.3发生早,显示乳腺癌发展的异质性

Available online /content/3/3/192 Primary research Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression † ‡ ‡ Kanokwan Kittiniyom*, Karen M Gorse , Fabienne Dalbegue , Jack H Lichy , Jeffery K Taubenberger‡ and Irene F Newsham*† *Department of Pathology and †Department of Anatomy, Virginia Commonwealth University, Richmond, Virginia, USA ‡Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, District of Columbia, USA Correspondence: Irene Newsham, PhD, Department of Neurosurgery, Henry Ford Hospital, ER Buillding, Room 3096, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Tel: +1 313 916 8640; fax: +1 413 487 9415; e-mail: irene@ Received: 18 September 2000 Breast Cancer Res 2001, 3:192–198 Revisions requested: 31 October 2000 This article may contain supplementary data which can only be found Revisions received: 5 December 2000 online at /content/3/3/192 Accepted: 19 January 2001 © 2001 Kittiniyom et al, licensee BioMed Central Ltd Published: 12 February 2001 (Print ISSN 1465-5411; Online ISSN 1465-542X) Abstract We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH