analysis of bordetella pertussis pertactin and pertussis toxin types from queensland, australia, 1999–2003分析百日咳博德特氏菌pertactin和百日咳毒素类型从昆士兰,澳大利亚,1999 - 2003.pdfVIP

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analysis of bordetella pertussis pertactin and pertussis toxin types from queensland, australia, 1999–2003分析百日咳博德特氏菌pertactin和百日咳毒素类型从昆士兰,澳大利亚,1999 - 2003.pdf

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analysis of bordetella pertussis pertactin and pertussis toxin types from queensland, australia, 1999–2003分析百日咳博德特氏菌pertactin和百日咳毒素类型从昆士兰,澳大利亚,1999 - 2003

BMC Infectious Diseases BioMed Central Research article Open Access Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999–2003 Shane Byrne*†1 and Andrew T Slack†1,2 Address: 1Public Health Microbiology, Queensland Health Scientific Services, Brisbane, Australia and 2Molecular Pathology Department, Sullivan Nicolaides Pathology, Brisbane, Australia Email: Shane Byrne* - Shane_Byrne@.au; Andrew T Slack - Andrew_Slack@.au * Corresponding author †Equal contributors Published: 16 March 2006 Received: 07 November 2005 Accepted: 16 March 2006 BMC Infectious Diseases2006, 6:53 doi:10.1186/1471-2334-6-53 This article is available from: /1471-2334/6/53 © 2006Byrne and Slack; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: In Australia two acellular Bordetella pertussis vaccines have replaced the use of a whole cell vaccine. Both of the licensed acellular vaccines contain the following three components; pertussis toxoid, pertussis filamentous haemagglutinin and the 69 kDa pertactin adhesin. One vaccine also contains pertussis fimbriae 2 and 3. Various researchers have postulated that herd immunity due to high levels of pertussis vaccination might be influencing the makeup of endemic B.