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analysis of global control of escherichia coli carbohydrate uptake分析全球控制大肠杆菌碳水化合物的吸收
BMC Systems Biology BioMed Central
Research article Open Access
Analysis of global control of Escherichia coli carbohydrate uptake
Andreas Kremling*, Katja Bettenbrock and Ernst Dieter Gilles
Address: Max-Planck-Institut Magdeburg, Systems Biology, Sandtorstr. 1, 39106 Magdeburg, Germany
Email: Andreas Kremling* - kremling@mpi-magdeburg.mpg.de; Katja Bettenbrock - bettenbrock@mpi-magdeburg.mpg.de;
Ernst Dieter Gilles - gilles@mpi-magdeburg.mpg.de
* Corresponding author
Published: 13 September 2007 Received: 8 May 2007
Accepted: 13 September 2007
BMC Systems Biology 2007, 1:42 doi:10.1186/1752-0509-1-42
This article is available from: /1752-0509/1/42
© 2007 Kremling et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Global control influences the regulation of many individual subsystems by
superimposed regulator proteins. A prominent example is the control of carbohydrate uptake
systems by the transcription factor Crp in Escherichia coli. A detailed understanding of the
coordination of the control of individual transporters offers possibilities to explore the potential
of microorganisms e.g. in biotechnology.
Results: An o.d.e. based mathematical model is presented that maps a
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