antibody-protein interactions benchmark datasets and prediction tools evaluation抗体蛋白质相互作用评价基准数据集和预测工具.pdfVIP

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antibody-protein interactions benchmark datasets and prediction tools evaluation抗体蛋白质相互作用评价基准数据集和预测工具.pdf

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antibody-protein interactions benchmark datasets and prediction tools evaluation抗体蛋白质相互作用评价基准数据集和预测工具

BMC Structural Biology BioMed Central Research article Open Access Antibody-protein interactions: benchmark datasets and prediction tools evaluation Julia V Ponomarenko*1,2 and Philip E Bourne 1,2 Address: 1San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA and 2Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA Email: Julia V Ponomarenko* - jpon@; Philip E Bourne - bourne@ * Corresponding author Published: 2 October 2007 Received: 9 April 2007 Accepted: 2 October 2007 BMC Structural Biology 2007, 7:64 doi:10.1186/1472-6807-7-64 This article is available from: /1472-6807/7/64 © 2007 Ponomarenko and Bourne.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The ability to predict antibody binding sites (aka antigenic determinants or B-cell epitopes) for a given protein is a precursor to new vaccine design and diagnostics. Among the various methods of B-cell epitope identification X-ray crystallography is one of the most reliable methods. Using these experimental data computational methods exist for B-cell epitope prediction. As the number of structures of antibody-protein complexes grows, further