原创力文档antiurolithic activity of origanum vulgare is mediated through multiple pathwaysantiurolithic牛至属植物的活性vulgare是通过多种途径介导的.pdfVIP
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antiurolithic activity of origanum vulgare is mediated through multiple pathwaysantiurolithic牛至属植物的活性vulgare是通过多种途径介导的
Khan et al. BMC Complementary and Alternative Medicine 2011, 11:96
/1472-6882/11/96
RESEARCH ARTICLE Open Access
Antiurolithic activity of Origanum vulgare is
mediated through multiple pathways
Aslam Khan1,2,3†, Samra Bashir2†, Saeed R Khan3† and Anwar H Gilani2,4*
Abstract
Background: Origanum vulgare Linn has traditionally been used in the treatment of urolithiasis. Therefore, we
investigated the crude extract of Origanum vulgare for possible antiurolithic effect, to rationalize its medicinal use.
Methods: The crude aqueous-methanolic extract of Origanum vulgare (Ov.Cr) was studied using the in vitro and in
vivo methods. In the in vitro experiments, supersaturated solution of calcium and oxalate, kidney epithelial cell lines
(MDCK) and urinary bladder of rabbits were used, whereas, in the in vivo studies, rat model of urolithiasis was used
for the study of preventive and curative effect.
Results: In the in vitro experiments, Ov.Cr exhibited a concentration-dependent (0.25-4 mg/ml) inhibitory effect on
the slope of nucleation and aggregation and also decreased the number of calcium oxalate monohydrate crystals
(COM) produced in calcium oxalate metastable solutions. It also showed concentration-dependent antioxidant
effect against DPPH free radical and lipid peroxidation induced in rat kidney tissue homogenate. Ov.Cr reduced the
cell toxicity using MTT assay and LDH release in renal epithelial cells (MDCK) exposed to oxalate (0.5 mM) and
COM (66 μg/cm2) crystals. Ov.Cr relaxed high K+ (80 mM) induced contraction in rabbit urinary bladder strips, and
shifted the calcium concentration-response curves (CRCs) towards right with suppression of the maximum
response similar to that of verapamil, a standard calcium channel blocker. In male Wistar rats receiving lithogenic
treatment comprising of 0.75% ethylene glyco
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