原创力文档architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks转录监管架构的电路是针织生物分子相互作用网络的拓扑结构.pdfVIP
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architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks转录监管架构的电路是针织生物分子相互作用网络的拓扑结构
BMC Systems Biology BioMed Central
Research article Open Access
Architecture of transcriptional regulatory circuits is knitted over
the topology of bio-molecular interaction networks
1 1 1,2
Ana Paula Oliveira , Kiran Raosaheb Patil* and Jens Nielsen*
Address: 1Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Building 223, DK-2800 Kgs.
Lyngby, Denmark and 2Current address: Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96
Gothenburg, Sweden
Email: Ana Paula Oliveira - apo@bio.dtu.dk; Kiran Raosaheb Patil* - krp@bio.dtu.dk; Jens Nielsen* - jn@bio.dtu.dk
* Corresponding authors
Published: 8 February 2008 Received: 12 September 2007
Accepted: 8 February 2008
BMC Systems Biology 2008, 2:17 doi:10.1186/1752-0509-2-17
This article is available from: /1752-0509/2/17
© 2008 Oliveira et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Uncovering the operating principles underlying cellular processes by using omics
data is often a difficult task due to the high-dimensionality of the solution space that spans all
interactions among the bio-molecules under consideration. A ra
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