原创力文档anticancer activity of a sub-fraction of dichloromethane extract of strobilanthes crispus on human breast and prostate cancer cells in vitro抗癌活性的二氯甲烷提取数目的一个分子strobilanthes管对人类乳腺癌和前列腺癌细胞体外.pdfVIP
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anticancer activity of a sub-fraction of dichloromethane extract of strobilanthes crispus on human breast and prostate cancer cells in vitro抗癌活性的二氯甲烷提取数目的一个分子strobilanthes管对人类乳腺癌和前列腺癌细胞体外
Yaacob et al. BMC Complementary and Alternative Medicine 2010, 10:42
/1472-6882/10/42
RESEARCH ARTICLE Open Access
Anticancer activity of a sub-fraction of
dichloromethane extract of Strobilanthes crispus
on human breast and prostate cancer cells
in vitro
1* 2 1 1
Nik Soriani Yaacob , Nurraihana Hamzah , Nik Nursyazni Nik Mohamed Kamal , Siti Amalina Zainal Abidin ,
2 2 3
Choon Sheen Lai , Visweswaran Navaratnam , Mohd Nor Norazmi
Abstract
Background: The leaves of Strobilanthes crispus (S. crispus) which is native to the regions of Madagascar to the
Malay Archipelago, are used in folk medicine for their antidiabetic, diuretic, anticancer and blood pressure lowering
properties. Crude extracts of this plant have been found to be cytotoxic to human cancer cell lines and protective
against chemically-induced hepatocarcinogenesis in rats. In this study, the cytotoxicity of various sub-fractions of
dichloromethane extract isolated from the leaves of S. crispus was determined and the anticancer activity of one of
the bioactive sub-fractions, SC/D-F9, was further analysed in breast and prostate cancer cell lines.
Methods: The dichloromethane extract of S. crispus was chromatographed on silica gel by flash column
chromatography. The ability of the various sub-fractions obtained to induce cell death of MCF-7, MDA-MB-231,
PC-3 and DU-145 cell lines was determined using the LDH assay. The dose-response effect and the EC50 values of
the active sub-fraction, SC/D-F9, were determined. Apoptosis was detected using Annexin V antibody and
propidium iodide staining and analysed by fluorescence microscopy and flo
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