antifungal susceptibility of invasive yeast isolates in italy the gisia3 study in critically ill patients抗真菌敏感性的侵入性酵母隔离在意大利gisia3研究危重病人.pdfVIP

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antifungal susceptibility of invasive yeast isolates in italy the gisia3 study in critically ill patients抗真菌敏感性的侵入性酵母隔离在意大利gisia3研究危重病人.pdf

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antifungal susceptibility of invasive yeast isolates in italy the gisia3 study in critically ill patients抗真菌敏感性的侵入性酵母隔离在意大利gisia3研究危重病人

Morace et al. BMC Infectious Diseases 2011, 11:130 /1471-2334/11/130 RESEARCH ARTICLE Open Access Antifungal susceptibility of invasive yeast isolates in Italy: the GISIA3 study in critically ill patients 1* 1 2 3 4 5 Giulia Morace , Elisa Borghi , Roberta Iatta , Gerardino Amato , Stefano Andreoni , Gioconda Brigante , 6 7 8 9 10 11 Claudio Farina , Giuliana Lo Cascio , Gianluigi Lombardi , Ester Manso , Michele Mussap , Patrizia Pecile , Roberto Rigoli12, Elisabetta Tangorra13, Maria Valmarin14 and Maria Teresa Montagna2 Abstract Background: Yeasts are a common cause of invasive fungal infections in critically ill patients. Antifungal susceptibility testing results of clinically significant fungal strains are of interest to physicians, enabling them to adopt appropriate strategies for empiric and prophylactic therapies. We investigated the antifungal susceptibility of yeasts isolated over a 2-year period from hospitalised patients with invasive yeast infections. Methods: 638 yeasts were isolated from the blood, central venous catheters and sterile fluids of 578 patients on general and surgical intensive care units and surgical wards. Etest strips and Sensititre panels were used to test the susceptibility of the isolates to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole, posaconazole and voriconazole in 13 laboratories centres (LC) and two co-ordinating centres (CC). The Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution method was used at the CCs for comparison. Results: Etest and Sensititre (LC/CC)