antihypertensive efficacy of metoprolol xllow dose chlorthalidone (6.25 mg) combination a randomized, comparative study in indian patients with mild-to-moderate essential hypertension抗高血压的功效美托洛尔xllow剂量氯噻酮(6.25毫克)随机组合,比较研究在印度轻中度原发性高血压患者.pdfVIP

Ju ly 22, 2009 EUROPEAN J OURNAL O MEDICAL RESEARCH 297 Eur J Med Res (2009) 14: 297-303 © I. Holzapfel Publishers 2009 ANTIHYPERTENSIVE E ICACY O METOPROLOL XL/LOW DOSE CHLORTHALIDONE (6.25 mg) COMBINATION: A RANDOMIZED, COMPARATIVE STUDY IN INDIAN PATIENTS WITH MILD-TO-MODERATE ESSENTIAL HYPERTENSION 1 2 3 4 5 A. Pareek , S. D. Zawar , S. B. Salagre , N. B. Chandurkar , N. D. Karnik 1Medical Affairs and Clinical Research, Ipca Laboratories Limited, Kandivli Industrial Estate, Kandivli (West), Mumbai, India 2Department of Medicine, Indira Gandhi Government Medical College and Mayo Hospital, Nagpur, India 3Department of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, India 4 Clinical Research and Development, Ipca Laboratories Limited, Kandivli Industrial Estate, Kandivli (West), Mumbai, India 5Department of Medicine, LTMM College and LTMG Hospital, Mumbai, India Abstract Key w ords: Beta-blocker, chlorthalidone, diuretics, es- Ob ective: High blood pressure is one of the most im- sential hypertension, metoprolol portant risk factors, directly responsible for increasing the cardiovascular morbidity and mortality. The prima- BACKGROUND ry objective was to evaluate the efficacy of metoprolol XL/chlorthalidone against metoprolol XL/hydro- Hypertension is a potent risk factor for all major car- chlorothiazide with respect to mean fall in systolic