原创力文档anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of thai medicinal plants in animal models对胆管癌抗癌活性,毒性和药理活性的泰国药用植物在动物模型.pdfVIP
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anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of thai medicinal plants in animal models对胆管癌抗癌活性,毒性和药理活性的泰国药用植物在动物模型
Plengsuriyakarn et al. BMC Complementary and Alternative Medicine 2012, 12:23
/1472-6882/12/23
RESEARCH ARTICLE Open Access
Anticancer activities against cholangiocarcinoma,
toxicity and pharmacological activities of Thai
medicinal plants in animal models
1 1 1 2 2
Tullayakorn Plengsuriyakarn , Vithoon Viyanant , Veerachai Eursitthichai , Porntipa Picha , Piengchai Kupradinun ,
Arunporn Itharat3 and Kesara Na-Bangchang1,4*
Abstract
Background: Chemotherapy of cholangiocarcinoma (CCA), a devastating cancer with increasing worldwide
incidence and mortality rates, is largely ineffective. The discovery and development of effective chemotherapeutics
is urgently needed.
Methods/Design: The study aimed at evaluating anticancer activities, toxicity, and pharmacological activities of the
curcumin compound (CUR), the crude ethanolic extracts of rhizomes of Zingiber officinale Roscoe (Ginger: ZO) and
Atractylodes lancea thung. DC (Khod-Kha-Mao: AL), fruits of Piper chaba Hunt. (De-Plee: PC), and Pra-Sa-Prao-Yhai
formulation (a mixture of parts of 18 Thai medicinal plants: PPF) were investigated in animal models. Anti-
cholangiocarcinoma (anti-CCA) was assessed using CCA-xenograft nude mouse model. The antihypertensive,
analgesic, anti-inflammatory, antipyretic, and anti-ulcer activities and effects on motor coordination were
investigated using Rota-rod test, CODA tail-cuff system, writhing and hot plate tests, carrageenan-induced paw
edema test, brewer’s yeast test, and alcohol-induced gastric ulcer test, respectively. Acute and subacute toxicity
tests were performed according to the OECD guideline for testing of chemicals with modification.
Results: Promising anticancer activity against CCA in
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