anti-hiv-1 activity of cellulose acetate phthalate synergy with soluble cd4 and induction of dead-end gp41 six-helix bundlesanti-hiv-1邻苯二甲酸醋酸纤维素酯的活性协同与可溶性cd4和感应终端gp41 six-helix包.pdfVIP

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anti-hiv-1 activity of cellulose acetate phthalate synergy with soluble cd4 and induction of dead-end gp41 six-helix bundlesanti-hiv-1邻苯二甲酸醋酸纤维素酯的活性协同与可溶性cd4和感应终端gp41 six-helix包.pdf

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anti-hiv-1 activity of cellulose acetate phthalate synergy with soluble cd4 and induction of dead-end gp41 six-helix bundlesanti-hiv-1邻苯二甲酸醋酸纤维素酯的活性协同与可溶性cd4和感应终端gp41 six-helix包

BMC Infectious Diseases BioMed Central BMC Infectious Diseases x 2002, 2 Research article Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of dead-end gp41 six-helix bundles A Robert Neurath*, Nathan Strick, Shibo Jiang, Yun-Yao Li and Asim K Debnath Address: Biochemical Virology Laboratory, The Lindsley F. Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA E-mail: A Robert Neurath* - arneurath@; Nathan Strick - nathan_strick@; Shibo Jiang - shibo_jiang@; Yun- Yao Li - yun-yao_li@; Asim K Debnath - asim_debnath@ *Corresponding author Published: 30 April 2002 Received: 14 December 2001 Accepted: 30 April 2002 BMC Infectious Diseases 2002, 2:6 This article is available from: /1471-2334/2/6 © 2002 Neurath et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, pro- vided this notice is preserved along with the articles original URL. Abstract Background: Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1 and to block the coreceptor binding site on the virus envelope glycoprotein gp120. It did not interfere with virus binding to CD4. Since CD4 is the primary cellular receptor for HIV-1, it was of interest to study CAP binding to HIV-1 complexes with soluble CD4 (sCD4) and its consequen