原创力文档anti-inflammatory effects of fermented and non-fermented sophora flavescens a comparative study抗炎作用的发酵和未发酵的概况进行比较研究.pdfVIP
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anti-inflammatory effects of fermented and non-fermented sophora flavescens a comparative study抗炎作用的发酵和未发酵的概况进行比较研究
Han et al. BMC Complementary and Alternative Medicine 2011, 11:100
/1472-6882/11/100
RESEARCH ARTICLE Open Access
Anti-inflammatory effects of fermented and non-
fermented Sophora flavescens: a comparative
study
1 2* 3*
Chun-chao Han , Hong Wei and Jianyou Guo
Abstract
Background: The roots of Sophora flavescens (Leguminosae) have been used in East Asian countries as an herbal
medicine and a food ingredient for thousands of years. The aim of the present study was to investigate the effects
of S. flavescens fermentation on endotoxin-induced uveitis (EIU) in rats.
Methods: EIU was induced in rats via a footpad injection of lipopolysaccharide (LPS). Immediately after the LPS
inoculation, fermented and non-fermented extracts of S. flavescens (FSE and NFSE, respectively) were administered
orally, and the aqueous humor was collected from both eyes 24 hours later. The anti-inflammatory effects of FSE
and NFSE were examined in terms of regulation of nuclear factor kappa B (NF-B) activation and the expression of
interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a), inducible nitric oxide synthase (iNOS), intercellular cell
adhesion molecule (ICAM)-1, and cyclooxygenase-2 (COX-2). The regulation of maleic dialdehyde (MDA) levels and
polymorphonuclear cell (PMN) infiltration by FSE and NFSE were also examined.
Results: Treatment with FSE significantly inhibited LPS-induced increases in IL-1b and TNF-a production and the
expression of iNOS, ICAM-1 and COX-2. Moreover, FSE suppressed LPS-induced NF-B activation, and reduced both
MDA levels and infiltration by PMN.
Conclusion: These results indicate that solid state fermentation may enhance the anti-inflammatory effects of S.
flavescens.
Background
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