原创力文档anti-hiv-1 activity of anionic polymers a comparative study of candidate microbicidesanti-hiv-1活性阴离子聚合物候选人杀微生物剂的比较研究.pdfVIP
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BMC Infectious Diseases BioMed Central
BMC Infectious Diseases x
2002, Open Access
2
Research article
Anti-HIV-1 activity of anionic polymers: a comparative study of
candidate microbicides
A Robert Neurath*, Nathan Strick and Yun-Yao Li
Address: Biochemical Virology Laboratory, The Lindsley F. Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
E-mail: A Neurath* - arneurath@; Nathan Strick - nathan_strick@; Yun-Yao Li - yun-yao_li@
*Corresponding author
Published: 21 November 2002 Received: 14 August 2002
Accepted: 21 November 2002
BMC Infectious Diseases 2002, 2:27
This article is available from: /1471-2334/2/27
© 2002 Neurath et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: Cellulose acetate phthalate (CAP) in soluble form blocks coreceptor binding sites
on the virus envelope glycoprotein gp120 and elicits gp41 six-helix bundle formation, processes
involved in virus inactivation. CAP is not soluble at pH 5.5, normal for microbicide target sites.
Therefore, the interaction between insoluble micronized CAP and HIV-1 was studied. Carbomer
974P/BufferGel; carrageenan; cellulose sulfate; dextran/dextrin sulfate, poly(napthalene sulfonate)
and poly(styrene-4-sulfonate) are also being considered as an
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