原创力文档anticonvulsant and neuroprotective effects of pimpinella anisum in rat brain抗癫痫和神经保护作用的pimpinella anisum在老鼠大脑.pdfVIP
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Karimzadeh et al. BMC Complementary and Alternative Medicine 2012, 12:76
/1472-6882/12/76
RESEARCH ARTICLE Open Access
Anticonvulsant and neuroprotective effects of
Pimpinella anisum in rat brain
1,2 3 4 2 5
Fariba Karimzadeh , Mahmoud Hosseini , Diana Mangeng , Hassan Alavi , Gholam Reza Hassanzadeh ,
5 1 6 1,4*
Mohamad Bayat , Maryam Jafarian , Hadi Kazemi and Ali Gorji
Abstract
Background: Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian
medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the
possible anti-seizure and anti-hypoxia effects of anise oil.
Methods: The effects of different concentrations of anise oil were tested on seizure attacks induced by
pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of
dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain.
Results: Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of
epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited
production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced
the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited
induction of LTP in hippocampal slices.
Conclusions: Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition
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