association between perinatal depression in mothers and the risk of childhood infections in offspring a population-based cohort study围产期抑郁症之间的联系在母亲和儿童感染的风险后代以人群为基础的队列研究.pdfVIP

Ban et al. BMC Public Health 2010, 10:799 /1471-2458/10/799 RESEARCH ARTICLE Open Access Association between perinatal depression in mothers and the risk of childhood infections in offspring: a population-based cohort study * † † Lu Ban , Jack E Gibson , Joe West, Laila J Tata Abstract Background: Previous studies have suggested that children of mothers who experience depression during the perinatal period may have more infections, but such studies are few in number and none have been carried out in the United Kingdom (UK) population. The aim of this study was to investigate the association between perinatal depression in mothers and the risk of childhood infections in offspring in the UK general population. Methods: We used data from The Health Improvement Network (THIN), a large database of electronic primary care medical records to conduct a cohort study among all first-born singleton children born and enrolled in THIN between 1988 and 2004. We used Poisson regression to compare the incidence of gastrointestinal infections and lower respiratory tract infections reported between birth and age 4 years among children of mothers with a record of perinatal depression with those born to mothers with no such history. Results: Children of mothers with perinatal depression had a 40% increased risk of gastrointestinal infections and a 27% increased risk of lower respiratory tract infections compared with children of mothers without perinatal depression (incidence rate ratios = 1.40 and 1.27; 95% confidence intervals 1.37-1.42 and 1.22-1.32, respectively). On restricting to antibiotic-treated infections there was a slight increase in the magnitude of association with gastrointestinal infections but a decrease in that with lower respiratory tract infections (incidence rate