association of beta3-adrenergic receptor (adrb3) trp64arg gene polymorphism with obesity and metabolic syndrome in the balinese a pilot study协会(adrb3)trp64arg beta3-adrenergic受体基因多态性与肥胖和代谢综合征在巴厘岛的一个试点研究.pdfVIP

Malik et al. BMC Research Notes 2011, 4:167 /1756-0500/4/167 SHORT REPORT Open Access Association of beta3-adrenergic receptor (ADRB3) Trp64Arg gene polymorphism with obesity and metabolic syndrome in the Balinese: a pilot study 1* 2 2 1 1 Safarina G Malik , Made R Saraswati , Ketut Suastika , Hidayat Trimarsanto , Sukma Oktavianthi and Herawati Sudoyo1 Abstract Background: Prevalence of obesity is increasing all over the world. ADRB3 Trp64Arg gene polymorphism was proposed to be associated with obesity, although inconsistent findings and differences of the Arg64 allele frequency among various ethnics were reported. Westernization was reported to increase the prevalence of obesity in developing world. In this study we determined the prevalence of obesity and metabolic syndrome among urban and rural Balinese, and studied the association of ADRB3 Trp64Arg polymorphism with obesity and MetS. Findings: A total of 528 Balinese (urban 282, rural 246) were recruited. Body mass index (BMI) and waist circumference (WC) were determined; high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), systolic and diastolic blood pressure (SBP and DBP), and fasting plasma glucose (FPG) were measured using standard procedures. BMI and WC classifications were based on WHO classifications for Asian. Metabolic syndrome (MetS) was defined as described in the Joint Interim Statement. Chi-square test was employed to test the association between the ADRB3 Trp64Arg genotype and disease traits. Urban have higher BMI (p = 2.8 × 10-13), WC ( p 2.2 × 10-16), TG (p = 0.0028), DBP (p = 1.8 × 10-5), and lower HDL-C (p = 0.0376) when compared to rural. Abdominal obesity and MetS prevalence were significantly h