association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes流通协会omentin-1水平与动脉硬化,在2型糖尿病颈动脉斑块.pdfVIP

association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes流通协会omentin-1水平与动脉硬化,在2型糖尿病颈动脉斑块.pdf

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association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes流通协会omentin-1水平与动脉硬化,在2型糖尿病颈动脉斑块

Yoo et al. Cardiovascular Diabetology 2011, 10:103 CARDIO /content/10/1/103 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes 1 2 1 1 1 1 1 Hye Jin Yoo , Soon Young Hwang , Ho Cheol Hong , Hae Yoon Choi , Sae Jeong Yang , Ji A Seo , Sin Gon Kim , 1 1 1 1* Nan Hee Kim , Kyung Mook Choi , Dong Seop Choi and Sei Hyun Baik Abstract Background: Adipokines contribute directly to the atherosclerotic process, connecting metabolic disorders such as obesity and diabetes to cardiovascular disease. Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited. Methods: We enrolled 60 people with type 2 diabetes, with or without carotid plaque, and 30 participants with normal glucose tolerance. We measured serum omentin-1, high-sensitivity C-reactive protein (hsCRP) levels, and the homeostasis model assessment of insulin resistance (HOMA-IR), as well as other cardiovascular risk factors. Vascular health was assessed by brachial ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT). Results: Serum omentin-1 levels were significantly decreased in type 2 diabetes patients compared to normal glucose controls and was further reduced in type 2 diabe

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