association of diminished expression of rassf1a with promoter methylation in primary gastric cancer from patients of central china协会的表达减弱rassf1a基因启动子甲基化在中国中部的主要患者的胃癌.pdfVIP

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association of diminished expression of rassf1a with promoter methylation in primary gastric cancer from patients of central china协会的表达减弱rassf1a基因启动子甲基化在中国中部的主要患者的胃癌.pdf

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association of diminished expression of rassf1a with promoter methylation in primary gastric cancer from patients of central china协会的表达减弱rassf1a基因启动子甲基化在中国中部的主要患者的胃癌

BMC Cancer BioMed Central Research article Open Access Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China 1 1 1 1 2 Mei Ye , Bing Xia* , Qiusha Guo , Feng Zhou and Xiaolian Zhang Address: 1Department of Internal Medicine Geriatrics, Research Centre of Digestive Diseases, Zhongnan Hospital, Wuhan University, PR China and 2Key Laboratory of Allergy and Immune-related Diseases, Wuhan University School of Medicine, Wuhan 430071, Hubei Province, PR China Email: Mei Ye - meiye16@; Bing Xia* - bingxia2004@; Qiusha Guo - sam77783@; Feng Zhou - zhouf04@; Xiaolian Zhang - zhangxl65@ * Corresponding author Published: 3 July 2007 Received: 3 March 2007 Accepted: 3 July 2007 BMC Cancer 2007, 7:120 doi:10.1186/1471-2407-7-120 This article is available from: /1471-2407/7/120 © 2007 Ye et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Although methylation-mediated inactivation of expression of RASSF1A, a candidate tumor suppressor gene, has been observed in several human cancers, the data concerning alteration of RASSF1A expression and methylation in Chinese primary gastric cance