association of hla class i and class ii genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11)协会的hla类我和bcr - abl成绩单和二类基因在白血病患者t(9;22)(q34;q11).pdfVIP

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association of hla class i and class ii genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11)协会的hla类我和bcr - abl成绩单和二类基因在白血病患者t(9;22)(q34;q11).pdf

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association of hla class i and class ii genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11)协会的hla类我和bcr - abl成绩单和二类基因在白血病患者t(9;22)(q34;q11)

BMC Cancer BioMed Central Research article Open Access Association of HLA Class I and Class II genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11) Shailendra Mundhada, Rajyalakshmi Luthra and Pedro Cano* Address: Department of Laboratory Medicine, Box 149, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030 Email: Shailendra Mundhada - sgmundha@; Rajyalakshmi Luthra - rluthra@; Pedro Cano* - pcano@ * Corresponding author Published: 17 June 2004 Received: 14 June 2003 Accepted: 17 June 2004 BMC Cancer 2004, 4:25 This article is available from: /1471-2407/4/25 © 2004 Mundhada et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Based on the site of breakpoint in t(9;22) (q34;q11), bcr-abl fusion in leukemia patients is associated with different types of transcript proteins. In this study we have seen the association of HLA genes with different types of bcr-abl transcripts. The association could predict the bcr-abl peptide presentation by particular HLA molecules. Methods: The study included a total of 189 patients of mixed ethnicity with chronic myelogenous leukemia and acute lymphocytic leukemia who were being considered for bone marrow transplantation. Typing of b