association of il-1beta gene polymorphism with cachexia from locally advanced gastric cancer协会il-1beta基因多态性与局部晚期胃癌的恶病质.pdfVIP

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association of il-1beta gene polymorphism with cachexia from locally advanced gastric cancer协会il-1beta基因多态性与局部晚期胃癌的恶病质.pdf

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association of il-1beta gene polymorphism with cachexia from locally advanced gastric cancer协会il-1beta基因多态性与局部晚期胃癌的恶病质

BMC Cancer BioMed Central Research article Open Access Association of IL-1beta gene polymorphism with cachexia from locally advanced gastric cancer 1 1 1 2 Dianliang Zhang* , Hongmei Zheng , Yanbing Zhou , Xingming Tang , 2 2 Baojun Yu and Jieshou Li Address: 1Department of General Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, P. R. China and 2Research Institute of General Surgery, Jinlin Hospital, Nanjing University, Nanjing 210093, P. R. China Email: Dianliang Zhang* - phdzdl@; Hongmei Zheng - surgerycn@163.com; Yanbing Zhou - wangdahai9988@; Xingming Tang - tangxingming@; Baojun Yu - nanjing_yubaojun@; Jieshou Li - surgerycn@ * Corresponding author Published: 14 March 2007 Received: 12 October 2006 Accepted: 14 March 2007 BMC Cancer 2007, 7:45 doi:10.1186/1471-2407-7-45 This article is available from: /1471-2407/7/45 © 2007 Zhang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: IL-1beta has been implicated in inflammatory episode. In view of the inflammatory nature of cancer cachexia, we determined the predictive value of IL-1B-31 T/C, -511 C/T, +3954 C/T and IL-1