association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men协会增加等离子体脂肪细胞脂肪酸结合蛋白与冠状动脉疾病的费用.pdfVIP

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association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men协会增加等离子体脂肪细胞脂肪酸结合蛋白与冠状动脉疾病的费用.pdf

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association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men协会增加等离子体脂肪细胞脂肪酸结合蛋白与冠状动脉疾病的费用

Doi et al. Cardiovascular Diabetology 2011, 10:44 CARDIO /content/10/1/44 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men 1 2,4* 3 4 5 1 Masayuki Doi , Toru Miyoshi , Satoshi Hirohata , Kazufumi Nakamura , Shinichi Usui , Ko Takeda , 1 5 4 4 Mutsumi Iwamoto , Shozo Kusachi , Kengo Kusano and Hiroshi Ito Abstract Background: Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD). Methods: Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were enrolled from inpatients who underwent coronary angiography. Age-matched male subjects (n = 211) having no evidence of CAD served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays. Results: Plasma A-FABP levels in CAD patients were significantly higher than in control subjects (median [IQR], 20.6 [15.7-27.8] ng/mL vs. 15.1 [11.7-19.9] ng/mL, p 0.01). Multivariate logistic regression analysis revealed that an increased plasma A-FABP level was independently associated with the presence of CAD in all subjects (adjusted