association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas an immunohistochemical study of clinically annotated tumors失去上皮syndecan-1协会与阶段和地方转移的大肠癌腺癌临床带注释的肿瘤的免疫组化染色.pdfVIP

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association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas an immunohistochemical study of clinically annotated tumors失去上皮syndecan-1协会与阶段和地方转移的大肠癌腺癌临床带注释的肿瘤的免疫组化染色.pdf

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association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas an immunohistochemical study of clinically annotated tumors失去上皮syndecan-1协会与阶段和地方转移的大肠癌腺癌临床带注释的肿瘤的免疫组化染色

BMC Cancer BioMed Central Research article Open Access Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tumors Yosuke Hashimoto†1,4, Marek Skacel†2,5 and Josephine C Adams*1,3 Address: 1Dept. of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA, 2Dept. of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, 44195, USA, 3Dept. of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA, 4Current Address: Shizuoka Cancer Center, Nagaizumi-cho, Sunto-gun 411-8777, Shizuoka, Japan and 5Current Address: Molecular Pathology Laboratory, Dahl-Chase Pathology Associates, 417 State Street (suite 540), Bangor, ME, 04401, USA Email: Yosuke Hashimoto - yo.hashimoto@scchr.jp; Marek Skacel - mskacel@; Josephine C Adams* - adamsj@ * Corresponding author †Equal contributors Published: 30 June 2008 Received: 14 February 2008 Accepted: 30 June 2008 BMC Cancer 2008, 8:185 doi:10.1186/1471-2407-8-185 This article is available from: /1471-2407/8/185 © 2008 Hashimoto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Syndecan-1 is a transmembrane proteoglycan with important roles in cell-cell and cell- extracellular