assessing protein similarity with gene ontology and its use in subnuclear localization prediction评估蛋白质相似基因本体及其使用亚核的定位预测.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Assessing protein similarity with Gene Ontology and its use in subnuclear localization prediction Zhengdeng Lei and Yang Dai* Address: Department of Bioengineering (MC063), University of Illinois at Chicago, 851 South Morgan Street, Chicago, IL 60607, USA Email: Zhengdeng Lei - zlei2@; Yang Dai* - yangdai@ * Corresponding author Published: 07 November 2006 Received: 11 July 2006 Accepted: 07 November 2006 BMC Bioinformatics 2006, 7:491 doi:10.1186/1471-2105-7-491 This article is available from: /1471-2105/7/491 © 2006 Lei and Dai; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The accomplishment of the various genome sequencing projects resulted in accumulation of massive amount of gene sequence information. This calls for a large-scale computational method for predicting protein localization from sequence. The protein localization can provide valuable information about its molecular function, as well as the biological pathway in which it participates. The prediction of localization of a protein at subnuclear level is a challenging task. In our previous work we proposed an SVM-based system using protein sequence information