assessing stability of gene selection in microarray data analysis评估基因选择在微阵列数据分析的稳定.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Assessing stability of gene selection in microarray data analysis Xing Qiu, Yuanhui Xiao, Alexander Gordon and Andrei Yakovlev* Address: Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA Email: Xing Qiu - xqiu@; Yuanhui Xiao - yxiao@; Alexander Gordon - Alexander_Gordon@; Andrei Yakovlev* - Andrei_Yakovlev@ * Corresponding author Published: 01 February 2006 Received: 17 August 2005 Accepted: 01 February 2006 BMC Bioinformatics 2006, 7:50 doi:10.1186/1471-2105-7-50 This article is available from: /1471-2105/7/50 © 2006 Qiu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The number of genes declared differentially expressed is a random variable and its variability can be assessed by resampling techniques. Another important stability indicator is the frequency with which a given gene is selected across subsamples. We have conducted studies to assess stability and some other properties of several gene selection procedures with biological and simulated data. Results: Using resampling techniques we have found that some genes are selected much less frequently (acro