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applications of microarray technology in breast cancer research微阵列技术在乳腺癌中的应用研究
Available online /content/3/3/158
Review
Applications of microarray technology in breast cancer research
Colin S Cooper
The Institute of Cancer Research, Sutton, Surrey, UK
Correspondence: Colin S Cooper, The Institute of Cancer Research, Haddow Laboratories, Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
E-mail: csc@icr.ac.uk
Received: 8 January 2001 Breast Cancer Res 2001, 3:158–175
Accepted: 1 February 2001 © 2001 BioMed Central Ltd
Published: 20 March 2001 (Print ISSN 1465-5411; Online ISSN 1465-542X)
Abstract
Microarrays provide a versatile platform for utilizing information from the Human Genome Project to
benefit human health. This article reviews the ways in which microarray technology may be used in
breast cancer research. Its diverse applications include monitoring chromosome gains and losses,
tumour classification, drug discovery and development, DNA resequencing, mutation detection and
investigating the mechanism of tumour development.
Keywords: drug discovery, genetic gains and losses, microarrays, microarray design, mutation detection, tumour
classification
Introduction bioinformatics, however, as information on this important
The Human Genome Project, which is nearing completion, area can be obtained from a number of sources (see [1]).
is expected to lead to the identification of up to 50,000
human genes. The key question now facing the cancer Microarray design
community is how to use information from this project for A
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