antenatal screening for hiv, hepatitis b and syphilis in the netherlands is effective产前筛查艾滋病毒、乙型肝炎和梅毒在荷兰是有效的.pdfVIP

Op de Coul et al. BMC Infectious Diseases 2011, 11:185 /1471-2334/11/185 RESEARCH ARTICLE Open Access Antenatal screening for HIV, hepatitis B and syphilis in the Netherlands is effective 1* 1 1 1 2 Eline LM Op de Coul , Susan Hahné , Yolanda WM van Weert , Petra Oomen , Colette Smit , 3 4 5 1 Kitty PB van der Ploeg , Daan W Notermans , Kees Boer and Marianne AB van der Sande Abstract Background: A screening programme for pregnant women has been in place since the 1950s in the Netherlands. In 2004 universal HIV screening according to opting out was implemented. Here, we describe the evaluation of the effectiveness of antenatal screening in the Netherlands for 2006-2008 for HIV, hepatitis B virus (HBV) and syphilis in preventing mother-to-child transmission, by using various data sources. Methods: The results of antenatal screening (2006-2008) were compared with data from pregnant women and newborns from other data sources. Results: Each year, around 185,000 pregnant women were screened for HIV, HBV and syphilis. Refusal rates for the screening tests were low, and were highest (0.2%) for HIV. The estimated annual prevalence of HIV among pregnant women was 0.05%. Prior to the introduction of screening, 5-10 children were born with HIV annually After the introduction of screening in 2004, only 4 children were born with HIV (an average of 1 per year). Two of these mothers had become pregnant prior to 2004; the third mother was HIV negative at screening and probably became infected after screening; the fourth mother’s background was unknown. Congenital syphilis was diagnosed in fewer th