analysis and comparison of very large metagenomes with fast clustering and functional annotation非常大的基因组的分析和比较快速聚类和功能注释.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Analysis and comparison of very large metagenomes with fast clustering and functional annotation Weizhong Li Address: California Institute for Telecommunications and Information Technology, University of California, San Diego, La Jolla California 92093 USA Email: Weizhong Li - liwz@ Published: 28 October 2009 Received: 16 March 2009 Accepted: 28 October 2009 BMC Bioinformatics 2009, 10:359 doi:10.1186/1471-2105-10-359 This article is available from: /1471-2105/10/359 © 2009 Li; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The remarkable advance of metagenomics presents significant new challenges in data analysis. Metagenomic datasets (metagenomes) are large collections of sequencing reads from anonymous species within particular environments. Computational analyses for very large metagenomes are extremely time-consuming, and there are often many novel sequences in these metagenomes that are not fully utilized. The number of available metagenomes is rapidly increasing, so fast and efficient metagenome comparison methods are in great demand. Results: The new metagenomic data analysis method Rapid Analysis of Multiple Metagenomes with