an in silico method for detecting overlapping functional modules from composite biological networks在硅片的方法检测重叠从复合生物网络功能模块.pdfVIP

BMC Systems Biology BioMed Central Research article Open Access An in silico method for detecting overlapping functional modules from composite biological networks Ioannis A Maraziotis*, Konstantina Dimitrakopoulou and Anastasios Bezerianos Address: Department of Medical Physics, School of Medicine, University of Patras, GR26500 Patras, Greece Email: Ioannis A Maraziotis* - ioannis@heart.med.upatras.gr; Konstantina Dimitrakopoulou - dimitrakopouloud@heart.med.upatras.gr; Anastasios Bezerianos - bezer@patreas.upatras.gr * Corresponding author Published: 1 November 2008 Received: 21 March 2008 Accepted: 1 November 2008 BMC Systems Biology 2008, 2:93 doi:10.1186/1752-0509-2-93 This article is available from: /1752-0509/2/93 © 2008 Maraziotis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The ever-increasing flow of gene expression and protein-protein interaction (PPI) data has assisted in understanding the dynamics of the cell. The detection of functional modules is the first step in deciphering the apparent modularity of biological networks. However, most network-partitioning algorithms consider only the topological aspects and ignore the underlying functional relationships. Results: In the current study we inte