amyloidogenic determinants are usually not buriedamyloidogenic因素通常不埋.pdfVIP

BMC Structural Biology BioMed Central Research article Open Access Amyloidogenic determinants are usually not buried † † Kimon K Frousios , Vassiliki A Iconomidou , Carolina-Maria Karletidi and Stavros J Hamodrakas* Address: Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece Email: Kimon K Frousios - kfrousios@biol.uoa.gr; Vassiliki A Iconomidou - veconom@biol.uoa.gr; Carolina- Maria Karletidi - carolinamaria05@; Stavros J Hamodrakas* - shamodr@biol.uoa.gr * Corresponding author †Equal contributors Published: 9 July 2009 Received: 7 April 2009 Accepted: 9 July 2009 BMC Structural Biology 2009, 9:44 doi:10.1186/1472-6807-9-44 This article is available from: /1472-6807/9/44 © 2009 Frousios et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Amyloidoses are a group of usually fatal diseases, probably caused by protein misfolding and subsequent aggregation into amyloid fibrillar deposits. The mechanisms involved in amyloid fibril formation are largely unknown and are the subject of current, intensive research. In an attempt to identify possible amyloidogenic regions in pr