an adenovirus primeplasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes腺病毒primeplasmid提高均等的免疫反应的诱导策略两个登革热病毒血清型.pdfVIP

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an adenovirus primeplasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes腺病毒primeplasmid提高均等的免疫反应的诱导策略两个登革热病毒血清型.pdf

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an adenovirus primeplasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes腺病毒primeplasmid提高均等的免疫反应的诱导策略两个登革热病毒血清型

BMC Biotechnology BioMed Central Research article Open Access An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes Saima Khanam, Pilankatta Rajendra, Navin Khanna and Sathyamangalam Swaminathan* Address: RGP Group, International Centre for Genetic Engineering Biotechnology, PO Box 10504, Aruna Asaf Ali Marg, New Delhi 110016, India Email: Saima Khanam - amias7@; Pilankatta Rajendra - rajmahav@yahoo.co.in; Navin Khanna - navin@icgeb.res.in; Sathyamangalam Swaminathan* - swami@icgeb.res.in * Corresponding author Published: 15 February 2007 Received: 23 August 2006 Accepted: 15 February 2007 BMC Biotechnology 2007, 7:10 doi:10.1186/1472-6750-7-10 This article is available from: /1472-6750/7/10 © 2007 Khanam et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Dengue is a public health problem of global significance for which there is neither an effective antiviral therapy nor a preventive vaccine. It is a mosquito-borne viral disease, caused by dengue (DEN) viruses, which are members of the Flaviviridae family. There are four closely related serotypes, DEN-1, DEN-2, DEN-3 and DEN-4, each of which is capable of causing disease. As immunity to any one serotype can potentially sensitize an ind