an active form of vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand积极形式的vav1诱发乳腺上皮细胞的迁移通过刺激分泌表皮生长因子受体配体.pdfVIP

Cell Communication and Signaling BioMed Central Research Open Access An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand Julie L Wilsbacher1,2, Sheri L Moores1,3 and Joan S Brugge* 1 Address: 1Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA, 2Current address : Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA and 3Current address : GlaxoSmithKline, Oncology, Collegeville, PA 19426, USA Email: Julie L Wilsbacher - julie.wilsbacher@; Sheri L Moores - sheri.l.moores@; Joan S Brugge* - jbrugge@ * Corresponding author Published: 18 May 2006 Received: 20 January 2006 Accepted: 18 May 2006 Cell Communication and Signaling 2006, 4:5 doi:10.1186/1478-811X-4-5 This article is available from: /content/4/1/5 © 2006 Wilsbacher et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Vav proteins are guanine nucleotide exchange factors (GEF) for Rho family GTPases and are activated following engagement of membrane receptors. Overexpression of Vav proteins enhances lamellipodium and ruffle formation, migration, and cell spreading, and augments activation of many downstream signaling proteins like Rac, ERK and Akt. Vav proteins are composed of multiple structur