an in vivo reporter of bmp signaling in organogenesis reveals targets in the developing kidneybmp信号的体内记者器官形成显示目标在发展中肾脏.pdfVIP

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an in vivo reporter of bmp signaling in organogenesis reveals targets in the developing kidneybmp信号的体内记者器官形成显示目标在发展中肾脏.pdf

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an in vivo reporter of bmp signaling in organogenesis reveals targets in the developing kidneybmp信号的体内记者器官形成显示目标在发展中肾脏

BMC Developmental Biology BioMed Central Research article Open Access An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney † † Ulrika Blank , Marianne L Seto , Derek C Adams, Don M Wojchowski, Michele J Karolak and Leif Oxburgh* Address: Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA Email: Ulrika Blank - Blanku@; Marianne L Seto - Setom@; Derek C Adams - Adamsd1@; Don M Wojchowski - Wojchd@; Michele J Karolak - Karolm@; Leif Oxburgh* - Oxburl@ * Corresponding author †Equal contributors Published: 18 September 2008 Received: 2 April 2008 Accepted: 18 September 2008 BMC Developmental Biology 2008, 8:86 doi:10.1186/1471-213X-8-86 This article is available from: /1471-213X/8/86 © 2008 Blank et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Bone morphogenetic proteins (BMPs) regulate essential processes during organogenesis, and a functional understanding of these secreted proteins depends on identification of their target cells. In this study, we generate a transgenic reporter for organogenesis studies that we use to define BMP pathway activation in the developing kidney.