anthracycline and concurrent radiotherapy as adjuvant treatment of operable breast cancer a retrospective cohort study in a single institution蒽环霉素和并发放疗作为可操作的乳腺癌的辅助治疗回顾性队列研究在一个单一的机构.pdfVIP

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anthracycline and concurrent radiotherapy as adjuvant treatment of operable breast cancer a retrospective cohort study in a single institution蒽环霉素和并发放疗作为可操作的乳腺癌的辅助治疗回顾性队列研究在一个单一的机构.pdf

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Ismaili et al. BMC Research Notes 2010, 3:247 /1756-0500/3/247 SHORT REPORT Open Access Anthracycline and concurrent radiotherapy as adjuvant treatment of operable breast cancer: a retrospective cohort study in a single institution 1,2* 3 3 1 1 1 Nabil Ismaili , Sanaa Elmajjaoui , Issam Lalya , Lamia Boulaamane , Rhizlane Belbaraka , Halima Abahssain , Rachi Aassab1 3 3 4 5 , Noureddine Benjaafar , Brahim El Khalil El Guddari , Omar El Mesbahi , Yassir Sbitti , 6 1 Mohammed Ismaili , Hassan Errihani Abstract Background: Concurrent chemoradiotherapy (CCRT) after breast surgery was investigated by few authors and remains controversial, because of concerns of toxicity with taxanes/anthracyclines and radiation. This treatment is not standard and is more commonly used for locally advanced breast cancer. The aim of our study was to evaluate the efficacy and safety of the concomitant use of anthracycline with radiotherapy (RT). Findings: Four hundred women having operable breast cancer, treated by adjuvant chemotherapy (CT) and RT in concomitant way between January 2001 and December 2003, were included in this retrospective cohort study. The study compares 2 adjuvant treatments using CCRT, the first with anthracycline (group A) and the second with CMF (group B). The CT treatment was repeated every 21 days for 6 courses and the total delivered dose of RT was 50 Gy, divided as 2 Gy daily fractions. Locoregional recurrence free (LRFS), event free (EFS), and overall survivals (OS) were estimated by the Kaplan-Meier method. The log-rank test was used