原创力文档analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis a case-control association study分析八个基因调节干扰素γ和人类遗传易感性肺结核病例对照关联研究.pdfVIP
- 1、本文档共9页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis a case-control association study分析八个基因调节干扰素γ和人类遗传易感性肺结核病例对照关联研究
Möller et al. BMC Infectious Diseases 2010, 10:154
/1471-2334/10/154
R E S E A R C H A R T I C L E Open Access
Research article
Analysis of eight genes modulating interferon
gamma and human genetic susceptibility to
tuberculosis: a case-control association study
1 2 1 2 1
Marlo Möller* , Almut Nebel , Paul D van Helden , Stefan Schreiber and Eileen G Hoal
Abstract
Background: Interferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium
tuberculosis, the causative pathogen of tuberculosis, and its role has been well established in animal models and in
humans. This cytokine is produced by activated T helper 1 cells, which can best deal with intracellular pathogens such
as M. tuberculosis. Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis
susceptibility, we investigated polymorphisms in eight candidate genes.
Methods: Fifty-four polymorphisms in eight candidate genes were genotyped in over 800 tuberculosis cases and
healthy controls in a population-based case-control association study in a South African population. Genotyping
methods used included the SNPlex Genotyping System™, capillary electrophoresis of fluorescently labelled PCR
products, TaqMan® SNP genotyping assays or the amplification mutation refraction system. Single polymorphisms as
well as haplotypes of the variants were tested for association with TB using statistical analyses.
Results: A haplotype in interleukin 12B was nominally associated with tuberculosis (p = 0.02), but after permutation
testing, done to assess the significance for the entire analysis, this was not globally significant. In addition a novel allele
was found for the interleukin 12B D5S2941 microsatellite.
Co
您可能关注的文档
- an individual-based network model to evaluate interventions for controlling pneumococcal transmission一个基于单独的网络模型,来评估干预措施控制肺炎球菌的传播.pdf
- an in vivo rna interference screen identifies gene networks controlling drosophila melanogaster blood cell homeostasis一个体内rna干扰屏幕识别基因网络控制果蝇血细胞内稳态.pdf
- an increased risk of urinary tract infection precedes development of primary biliary cirrhosis尿路感染的风险增加先于原发性胆汁性肝硬化的发展.pdf
- an informatics search for the low-molecular weight chromium-binding peptide的信息搜索低分了体重chromium-binding肽.pdf
- an industry consensus study on an hplc fluorescence method for the determination of (±)-catechin and (±)-epicatechin in cocoa and chocolate products研究一个行业共识的高效液相色谱荧光法测定(±)儿茶素和表儿茶素(±)在可可和巧克力产品.pdf
- an in vivo reporter of bmp signaling in organogenesis reveals targets in the developing kidneybmp信号的体内记者器官形成显示目标在发展中肾脏.pdf
- an information-flow-based model with dissipation, saturation and direction for active pathway inferenceinformation-flow-based模型与耗散,饱和度和方向的活动路径推理.pdf
- an inhibitor of k+ channels modulates human endometrial tumor-initiating cells抑制剂的k +通道调节人类子宫内膜肿瘤起源细胞.pdf
- an innovative approach for testing bioinformatics programs using metamorphic testing一个创新的方法测试生物信息学程序使用变质测试.pdf
- an innovative approach to developing the reflective skills of medical students一个创新的方法来发展医学生的反思能力.pdf
文档评论（0）