applying negative rule mining to improve genome annotation应用负规则挖掘提高基因组注释.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Applying negative rule mining to improve genome annotation 1,2 1 1,3 Irena I Artamonova , Goar Frishman and Dmitrij Frishman* Address: 1Institute for Bioinformatics, GSF – National Research Center for Environment and Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany, 2Group of Bioinformatics, Vavilov Institute of General Genetics RAS, Gubkina 3, 119991 Moscow, Russia and 3Department of Genome Oriented Bioinformatics, Technische Universität Munchen, Wissenschaftzentrum Weihenstephan, 85350 Freising, Germany Email: Irena I Artamonova - irena.artamonova@gsf.de; Goar Frishman - astva@gsf.de; Dmitrij Frishman* - d.frishman@wzw.tum.de * Corresponding author Published: 21 July 2007 Received: 22 March 2007 Accepted: 21 July 2007 BMC Bioinformatics 2007, 8:261 doi:10.1186/1471-2105-8-261 This article is available from: /1471-2105/8/261 © 2007 Artamonova et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Unsupervised annotation of proteins by software pipelines suffers from very high error rates. Spurious functional assignments are usually caused by unwarranted homology-based tr