application of protein structure alignments to iterated hidden markov model protocols for structure prediction应用蛋白质结构调整迭代隐马尔可夫模型用于结构预测的协议.pdfVIP

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application of protein structure alignments to iterated hidden markov model protocols for structure prediction应用蛋白质结构调整迭代隐马尔可夫模型用于结构预测的协议.pdf

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application of protein structure alignments to iterated hidden markov model protocols for structure prediction应用蛋白质结构调整迭代隐马尔可夫模型用于结构预测的协议

BMC Bioinformatics BioMed Central Research article Open Access Application of protein structure alignments to iterated hidden Markov model protocols for structure prediction Eric D Scheeff*1,3 and Philip E Bourne 1,2 Address: 1San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0537, USA, 2Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA and 3Present address: Razavi-Newman Center for Bioinformatics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd., La Jolla, CA 92037, USA Email: Eric D Scheeff* - scheeff@; Philip E Bourne - bourne@ * Corresponding author Published: 14 September 2006 Received: 18 April 2006 Accepted: 14 September 2006 BMC Bioinformatics 2006, 7:410 doi:10.1186/1471-2105-7-410 This article is available from: /1471-2105/7/410 © 2006 Scheeff and Bourne; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. Because profiles are built from sequence alignments, the sequences included in the alignment and the method used to align them will be important to the sensitivity of the r