association of the 4？g5？g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. a case control study协会4 g5 g纤溶酶原激活物inhibitor-1基因的多态性与突然的感音神经性听力损失。.pdfVIP

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association of the 4？g5？g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. a case control study协会4 g5 g纤溶酶原激活物inhibitor-1基因的多态性与突然的感音神经性听力损失。.pdf

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association of the 4？g5？g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. a case control study协会4 g5 g纤溶酶原激活物inhibitor-1基因的多态性与突然的感音神经性听力损失。

Cho et al. BMC Ear, Nose and Throat Disorders 2012, 12:5 /1472-6815/12/5 RESEARCH ARTICLE Open Access Association of the 4 g/5 g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. A case control study 1,2* 1 1 1 1 1 3 4 Seong Ho Cho , Haimei Chen , Il Soo Kim , Chio Yokose , Joseph Kang , David Cho , Chun Cai , Silvia Palma , 5 5 3 Micol Busi , Alessandro Martini and Tae J Yoo Abstract Background: The 5 G/5 G genotype of PAI-1 polymorphism is linked to decreased plasminogen activator inhibitor-1 (PAI-1) levels and it has been suggested that lower PAI-1 levels may provide protective effects on inflammation, local microcirculatory disturbance, and fibrotic changes, which are likely associated with development of sudden sensorineural hearing loss (SSNHL). Methods: The association of the 4 G/5 G PAI-1 polymorphism with the development and clinical outcome of SSNHL is evaluated via a case control study. 103 patients with SSNHL and 113 age and sex-matched controls were enrolled at University of Ferrara, Italy and hearing loss outcome was measured at least 3 months after the onset of hearing loss. DNA was isolated from peripheral blood using the QIAamp kit and the 4 G/5 G polymorphism in the −675 promoter region was genotyped with an allele-specific PCR. Genotype distribution was tested in patients and compared to controls by chi-square and odd-ratio analysis. The codominant and recessive models were used for the multiple logistic regression analyses of the PAI-1 gene allele. Results: In this population, 5 G/5 G genotype had a two-time lower frequency in SSNHL patients compared to healthy