原创力文档augmented annotation and orthologue analysis for oryctolagus cuniculus better bunny增强注释和orthologue分析oryctolagus cuniculus更好的兔子.pdfVIP
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augmented annotation and orthologue analysis for oryctolagus cuniculus better bunny增强注释和orthologue分析oryctolagus cuniculus更好的兔子
Craig et al. BMC Bioinformatics 2012, 13:84
/1471-2105/13/84
SOFTWARE Open Access
Augmented annotation and orthologue analysis
for Oryctolagus cuniculus: Better Bunny
1 1,2 1*
Douglas B Craig , Sujatha Kannan and Alan A Dombkowski
Abstract
Background: The rabbit is an important model organism used in a wide range of biomedical research. However,
the rabbit genome is still sparsely annotated, thus prohibiting extensive functional analysis of gene sets derived
from whole-genome experiments. We developed a web-based application that provides augmented annotation
and orthologue analysis for rabbit genes. Importantly, the application allows comprehensive functional analysis
through the use of orthologous relationships.
Results: Using data extracted from several public bioinformatics repositories we created Better Bunny, a database
and query tool that extensively augments the available functional annotation for rabbit genes. Using the complete
set of target genes from a commercial rabbit gene expression microarray as our benchmark, we are able to obtain
functional information for 88 % of the genes on the microarray. Previously, functional information was available for
fewer than 10 % of the rabbit genes.
Conclusions: We have developed a freely available, web-accessible bioinformatics tool that enables investigators to
quickly and easily perform extensive functional analysis of rabbit genes (). The software
application fills a critical void for a wide range of biomedical research that relies on the rabbit model and requires
characterization of biological function for large sets of genes.
Keywords: Rabbit, Genome, Annotation, Orthologue, Microarray, Functional analysis
Background
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