原创力文档autoreactive marginal zone b cells enter the follicles and interact with cd4+ t cells in lupus-prone miceautoreactive边缘区b细胞进入毛囊与cd4 + t细胞在lupus-prone老鼠.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
autoreactivemarginalzonebcellsenterthefolliclesandinteractwithcd4tcellsinlupus-pronemiceautoreactive边缘区b细胞进入毛囊与cd4t细胞在lupus-prone老鼠
Zhou et al. BMC Immunology 2011, 12:7
/1471-2172/12/7
RESEARCH ARTICLE Open Access
Autoreactive marginal zone B cells enter the
follicles and interact with CD4+ T cells in
lupus-prone mice
1,2 1,3 1 1*
Zhenhai Zhou , Haitao Niu , Ying-Yi Zheng , Laurence Morel
Abstract
Backgound: Marginal zone B cells have been implicated in the production of autoantibodies in murine models of
lupus. It has been suggested that they contribute to lupus immunopathogenesis through their enhanced effector
functions and their repertoire that is biased toward autoreactive specificities. In the B6.NZM2410.Sle.Sle2.Sle3 (B6.TC)
model of lupus, the majority of marginal zone B cells are located outside the marginal zone and inside the follicles.
Genetic alterations of this strain have shown a correlation between autoimmune pathogenesis and the presence of
intrafollicular marginal zone B cells. This study was designed first to strengthen our original observations and to
determine how the marginal zone B cells from the lupus-prone mice respond to stimulations and interact with T cells.
Results: The intrafollicular location of B6.TC MZB cells starts before disease manifestations and puts MZB cells in
direct contact with CD4+ T cells. Two different autoreactive B cell receptor (BCR) transgenic models showed that
the expression of the Sle susceptibility loci enhances the presence of MZB cells inside the follicles. In vitro, B6.TC
MZB cells were better effectors than B6 MZB cells with enhanced proliferation and antibody (Ab) production,
including anti-DNA Ab, in response to stimulation with TLR ligands, immune complexes or anti-CD40. Furthermore,
B6.TC MZB and CD4+ T cells showed a reciprocally enhanced activation, which indicated that their contacts inside
B6.T
您可能关注的文档
- associations between genetic variations in the furin gene and hypertensionfurin基因的遗传变异和高血压之间的联系.pdf
- associations among different functional and structural arterial wall properties and their relations to traditional cardiovascular risk factors in healthy subjects a cross-sectional study不同功能和结构之间的关联动脉壁属性及其关系与传统心血管危险因素在健康受试者的横断面研究.pdf
- associations between preschool attendance and developmental impairments in pre-school children in a six-year retrospective survey幼儿出勤和发育障碍之间的关联在学龄前儿童六年回顾性调查.pdf
- associations between lamb survival and prion protein genotype analysis of data for ten sheep breeds in great britain羊肉生存和朊蛋白基因型之间的关联数据分析十羊品种在英国.pdf
- associations between partial sickness benefit and disability pensions initial findings of a finnish nationwide register study之间的联系部分疾病补助费和残疾退休金的芬兰全国注册研究的初步结果.pdf
- associations between quality indicators of internal medicine residency training programs内科住院医师培训项目质量指标之间的关联.pdf
- association, effects and validation of polymorphisms within the ncapg - lcorl locus located on bta6 with feed intake, gain, meat and carcass traits in beef cattle协会、效果和验证ncapgu2014u2014lcorl内的多态性位点位于bta6采食量,增益,肉和牛肉胴体性状.pdf
- associations between statins and copd a systematic review他汀类药物之间的关联和慢性阻塞性肺病系统回顾.pdf
- associations between sexual behaviour change in young people and decline in hiv prevalence in zambia年轻人的性行为改变之间的联系和赞比亚艾滋病毒流行率下降.pdf
- associations between subspecialty fellowship interest and knowledge of internal medicine a hypothesis-generating study of internal medicine residents内科医学附属专业奖学金的兴趣和知识之间的关联的存活率存在研究内科居民.pdf
- avoidable mortality from giving tranexamic acid to bleeding trauma patients an estimation based on who mortality data, a systematic literature review and data from the crash-2 trial可避免死亡率提供氨甲环酸估计基于出血创伤病人死亡率数据,一个系统的文献回顾从crash-2试验和数据.pdf
- avoidance as a strategy of (not) coping qualitative interviews with carers of huntington's disease patients回避的策略(不)应对定性采访亨廷顿氏舞蹈症患者的护理人员.pdf
- avoidance behaviors and negative psychological responses in the general population in the initial stage of the h1n1 pandemic in hong kong回避行为和消极心理反应在一般人群在香港h1n1大流行性流感的初始阶段.pdf
- autosome a clustering method for identifying gene expression modules without prior knowledge of cluster number常染色体基因表达聚类方法确定模块没有先验知识集群数量.pdf
- auxin-inducible protein depletion system in fission yeast在裂殖酵母auxin-inducible蛋白质消耗系统.pdf
- automics an integrated platform for nmr-based metabonomics spectral processing and data analysis全自动集成平台nmr-based代谢组学光谱处理和数据分析.pdf
- awareness and utilization of modern contraceptives among street women in north-west ethiopia认识和利用现代避孕在街道妇女埃塞俄比亚西北部.pdf
- avid an integrative framework for discovering functional relationships among proteins狂热的一个综合框架,用于发现功能性蛋白质之间的关系.pdf
- awareness and practice of patient's rights law in lithuania认识和实践在立陶宛病人的权利的法律.pdf
- awareness of health effects of cooking smoke among women in the gondar region of ethiopia a pilot survey女性意识的烹调烟雾对健康的影响在埃塞俄比亚的贡德尔地区试点调查.pdf
文档评论（0）