avid an integrative framework for discovering functional relationships among proteins狂热的一个综合框架,用于发现功能性蛋白质之间的关系.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access AVID: An integrative framework for discovering functional relationships among proteins Taijiao Jiang and Amy E Keating* Address: Department of Biology, Massachusetts Institute of Technology, Cambridge, USA Email: Taijiao Jiang - taijiao@; Amy E Keating* - keating@ * Corresponding author Published: 01 June 2005 Received: 14 December 2004 Accepted: 01 June 2005 BMC Bioinformatics 2005, 6:136 doi:10.1186/1471-2105-6-136 This article is available from: /1471-2105/6/136 © 2005 Jiang and Keating; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Determining the functions of uncharacterized proteins is one of the most pressing problems in the post-genomic era. Large scale protein-protein interaction assays, global mRNA expression analyses and systematic protein localization studies provide experimental information that can be used for this purpose. The data from such experiments contain many false positives and false negatives, but can be processed using computational methods to provide reliable information about protein-protein relationships and protein function. An outstanding and important goal is to predict detailed functional annotation for all uncharact